Čes. stomatol. Prakt. zub. lék. (Czech Dental Journal) 1999; 99(4): 107-111
The Role of External and Internal Factors in the Pathogenesis of Periodontitis and the Importance of Conservative Treatment
- Výzkumný ústav stomatologický, Praha, ředitel MUDr. O. Krejsa, csc.
The ability of bacteria of dental plaque to activate metalloproteinases may beone of the key mechanisms of damage of the periodontal tissue. In a group of patients with early onset periodontitis the authors investigated in the sulcular fluid, using the ELISAmethod, levels of the tissue plasminogen activator (tPA) and the effect of conservative and antibiotic treatment. Reduction of the tissue plasminogen activator (tPA) in sulcular fluid was influenced most by conservative treatment, three months after antibiotic treatment a lowerlevel was recorded still in six of eight samples. The authors found that in treatment of periodontitis the most important part is played by conservative treatment. An important rolein the treatment of periodontitis is, however, played by all drugs which inactivate metalloproteinases.
Keywords: periodontitis; conservative therapy; metalloproteinases
Published: December 1, 1999 Show citation
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