Čes. stomatol. Prakt. zub. lék. (Czech Dental Journal) 2005; 105(1): 7-11

Titanium Disc Modified with Hydroxyapatite and Zirconia Does not Reveal Signs of Cytotoxicity

Z. Teuberová1, M. Seydlová1, T. Dostálová1, M. Jelínek2, B. Dvořánková3
1 Stomatologická klinika 1. LF UK a VFN Praha, přednosta prof. MUDr. J. Mazánek, DrSc.
2 Fyzikální ústav AV ČR, Praha ředitel Ing. K. Jungwirth, DrSc.
3 Klinika popáleninové medicíny 3. LF UK Praha, přednosta MUDr. L. Brož

The paper deals primarily with the study of biological properties of a model of implant covered with a thin layer of hydroxyapatite with an intermediate layer of zirconium. Cytotoxicity was evaluated by direct cultivation with mouse and human fibroblasts. A physical test using X-ray diffraction confirmed that the film is composed of crystalline hydroxyapatite. The evaluation of the cytotoxicity test and a comparison with controlled samples cultured in parallel in vitro made it possible to conclude that the material is not cytotoxic audit is suitable for further experiments in more detail.

Keywords: implant; hydroxyapatite; zirconium; X-ray diffraction; direct cytotoxicity test

Published: March 1, 2005  Show citation

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Teuberová Z, Seydlová M, Dostálová T, Jelínek M, Dvořánková B. Titanium Disc Modified with Hydroxyapatite and Zirconia Does not Reveal Signs of Cytotoxicity. Čes. stomatol. Prakt. zub. lék. 2005;105(1):7-11.
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