Čes. stomatol. Prakt. zub. lék. (Czech Dental Journal) 2008; 108(2): 35-38

Oral Lichen Planus - Present Knowledge

I. Dřízhal*, V. Paulusová
Stomatologická klinika LF UK a FN, Hradec Králové

Oral lichen planus (OLP) and recurrent aphtous stomatitis are the most frequent diseases of oral mucosa. Epidemiologic studies are demonstrating the frequency of 1-2 % in adult population. OLP is very frequently discussed in scientific literature. However, the etiology remains still unclear. Pathogenetic processes of OLP are partly elucidated. Changes involving the region of basal membrane are suggested to be the result of the apoptosis of keratinocytes. Apoptosis of keratinocytes is caused by CD8+Tlymphocytes. These cells are activated by TNFα. After the death of keratinocytes the stability of the basal membrane is changed, the basal membrane is splitted (teared). MMP 9 is involved in enhacing the process. Actually it is impossible to explore this knowledge in the treatment of OLP because the initial factor of the pathogenetic process is unknown.

Keywords: Oral lichen planus (OLP); pathogenesis OLP; histological findings

Published: June 1, 2008  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Dřízhal I, Paulusová V. Oral Lichen Planus - Present Knowledge. Čes. stomatol. Prakt. zub. lék. 2008;108(2):35-38.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Agarwal, R., Saraswat, A.: Oral lichen planus: an update. Drugs Today, 38, 2002, s. 533-547. Go to original source... Go to PubMed...
    2. Andreasen, J. O.: Oral lichen planus. A clinical evaluation of 115 cases. Oral Surg Oral Med Oral Pathol, 25, 1968, s. 31-42. Go to original source...
    3. Axell, T., Runquist, L.: Oral lichen planus - a demographic study. Comm. Dent. Oral Epidemiol., 15, 1987, s. 52-56. Go to original source... Go to PubMed...
    4. Burkhart, N. W., Burker, E. J., Burkes, E. J., Wolfe, L.: Assessing the characteristics of patients with oral lichen planus. JADA, 127, 1996, s. 648-662. Go to original source... Go to PubMed...
    5. Carrozo, M., Francia Di Celle, P., Gandolfo, S. et al.: Increased frequency of HLA-DR 6 allele in Italien patients with hepatitis C virus - associated oral lichen planus. Br. J. Dermatos., 144, 2001, s. 803-808. Go to original source... Go to PubMed...
    6. Dissemond, J.: Oral lichen planus: An overview. J. Dermatos. Treat., 15, 2004, s. 136-140. Go to original source... Go to PubMed...
    7. Dřízhal, I., Dítě, P.: Hladina vit. A u lichen planus a leukoplakií. Čs. Dermatol., 47, 1972, s. 74-76.
    8. Eisenberg, F: Oral lichen planus: a benign lesion. J. Oral. Maxillofacial. Surg., 58, 2000, s. 1278-1285. Go to original source... Go to PubMed...
    9. Eisen, D: The clinical features, malignant potential, and systemic assotiations of oral lichen planus. A study of 723 patients. J. Am. Acad. Dermatos, 46, 2002, s. 207-214. Go to original source... Go to PubMed...
    10. Eversole, L. R.: Immunopathogenesis of oral lichen planus and reccurent aphtous stomatitis. Semin Cutan Med. Surg., 16, 1997, s. 284-294. Go to original source... Go to PubMed...
    11. Femiano, F., Cozzalino, F., Gaeta, G. M., De Luca P., Perffetto, B., Baroni, A.: Recent advances on the pathogenesis of oral lichen planus (OLP): the adhesions molecules. Minerva Stomatol, 48, 1999, s. 151-159. Go to PubMed...
    12. Firth, N. A., Rich, A. M., Radden, B. G, Reade, P. C.: Assessment of the value of immunofluorescence microscopy in the diagnosis of oral mucosal lichen planus. J. Oral Pathol Med, 219, 1990, s. 295-197. Go to original source... Go to PubMed...
    13. Harden, D., Skeleton, H., Smith, K. J.: Lichen planus associated with hepatitis C virus: no viral transcripts are found in the lichen planus, and effective therapy for hepatitis C virus does not clear lichen planus. J. Amer. Acad. Dermatol, 49, 2003, s. 847-852. Go to original source... Go to PubMed...
    14. Chinami, W. N., Silverman, S., Lotara-Nur, N., Mayer, P., Watson, J. J.: Oral lichen planus. Patients progression and treatment response. JADA, 132, 2001, s. 901-909. Go to original source... Go to PubMed...
    15. Ivanovski, K., Nakova, M., Warburton, G., Pesevska, S., Filipovska, A., Nares, S., Nunn, M. E., Angelova, D., Angelov, N.: Psychological profile in oral lichen planus. J. Clin. Periodontol, 32, 2005, s. 1034-1040. Go to original source... Go to PubMed...
    16. Junggell, P., Kontinnen, Y. T,, Nortamo, P. et al.: Immunoelectron microscopic study of distribution of T-cells subjects in oral lichen planus. Scand. J. Dent. Res., 976, 1989, s. 361-367. Go to original source... Go to PubMed...
    17. Kalfus, P., Dřízhal, I., Živný, P.: Orální lichen planus a hepatitida C. LKS, 16, 2006, s. 19-21.
    18. Klpi, A. M.: Activation marker analysis of mononuclear cell infiltrates of oral lichen planus in situ. Scand. J. Dent. Res., 95, 1987, s. 174-180. Go to original source... Go to PubMed...
    19. Kragerlund, C., Thomsen, C. E., Bardka, A., Pedersen, A. M., Nauntofte, B., Rebel J., Torpet: Oral lichen planus and intake of drugsa metabolized by polymorphic cytochrome P 450 enzymes. Oral. Dis., 9, 2003, s. 177-187. Go to original source... Go to PubMed...
    20. Lodig, G., Porter, S. R.: Hepatitis C virus infection and lichen planus: A short review. Oral. Dis., 3, 1997, s. 77-81. Go to original source... Go to PubMed...
    21. Mignona, M. D., Lo Muzio, L., Lo Ruso, L. et al.: Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5 years experience. Oral Oncol., 37 2001, s. 262-267. Go to original source... Go to PubMed...
    22. Nickoloff, B. J., Lewinsohn, D. M., Butcher, F. C.: Enhaced binding of periferal blood mononuclear leukocytes to gamma-interferon-treated cultured keratinocytes. Amer. J. Dermatopathol, 9, 1987, s. 413-418. Go to original source... Go to PubMed...
    23. Porter, S. R., Kirly, A., Olsen, I., Barrett, W.: Immunologic aspects of dermal and oral lichen planus: a review., Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 83, 1997, s. 358-366. Go to original source... Go to PubMed...
    24. Sand, L. P, Jalouli, J., Larson, P. A., Hirch, J. M.: Prevalence of Epstei-Barr virus in oral squamous carcinoma, oral lichen planus and normal oral mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 93, 2002, s. 586-592. Go to original source... Go to PubMed...
    25. Scully, C., Beyli, M., Fereiro, M. C., Ficarra, G., Gill, Y., Griffith, M. et al.: Update on oral lichen planus: etiopathogenesis and management., Crit. Rev. Oral. Biol. Med., 9, 1998, s. 86-122. Go to original source... Go to PubMed...
    26. Silverman, S.: Oral lichen planus: a potentially premalignant lesions, J. Oral. Maxillofac. Surg., 58, 2000, s. 1286-1288. Go to original source... Go to PubMed...
    27. Superman, P. B., Sabate, N. W., Xijing Zhou, Walsh, L. J., Bitvy, M.: Oral lichen planus: Pathogenesis and treatment. Clin. Dermatos., 18, 2000, s. 533-539. Go to original source... Go to PubMed...
    28. Superman, P. B., Sabate, N. W., Walsh, I. J., Zhao, Z. Z., Zhou, X. J., Khan, A., Seymour, G. J., Bitvy, M.: The pathogenesis of oral lichen planus. Crit. Rev. Oral. Biol., 13, 2002, s. 350-365. Go to original source... Go to PubMed...
    29. Valente, G., Pagano, M., Carrozo, M. et al.: Sequencial immunohistochemical p 53 exprassion on biopsis of oral lichen planus undergoing malignant evolution. J. Oral. Pathol. Med., 30, 2001, s. 135-140. Go to original source... Go to PubMed...
    30. Van der Meij, E. H., Schepman, K. P., Semele, L. E., van der Wall, I.: A review of recent literature regarding malignant transformation of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 88, 1999, s. 307-310. Go to original source... Go to PubMed...
    31. Vente, C., Reich, K., Rumprecht, R., Neumann, C.: Erosive mucosal lichen planus response to topical treatment with tacrolimus. Br. J. Dermatos, 140, 1999, s. 338-342. Go to original source... Go to PubMed...
    32. Walton, L. J., Thornhill, M. H., Farthing, P. M.: VCAM-1 and ICAM 1 are expressed by Langerhans cells, macrophages and endothelial cells in oral lichen planus. J. Oral. Pathol. Med., 23, 1994, s. 262-268. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content