Čes. stomatol. Prakt. zub. lék. (Czech Dental Journal) 2015; 115(3): 27-33 | DOI: 10.51479/cspzl.2015.021

New Pharmacotherapeutic Posssibilities in Contemporary Dentistry

R. Slezák*, Z. Janovská, I. Lindrová, V. Radochová
Stomatologická klinika LF UK a FN, Hradec Králové

Background: Both new active substances and medical devices are used in dentistry. Especially some diseases of the mucous membrane of the mouth, lip vermillion, salivary glands, and bone of jaws are the major focus on drug development. An acyclic nucleoside antiviral analogue Zovirax Duo containing aciclovir and cortisol is the cream peparation for topical treatment of labial herpes with additional antiinflammatory effect. Filmogel® URGO Afty gel was designed for topical therapy of recurrent aphthous ulcers. Emofix gel was designed for local therapy of mucosal bleeding of various origin. Betaine, xylitol and olive oil containing products (Xerostom) have been declared for both substitutional and stimulating therapy of hyposialia of various origin. There are initial reports about the use of bone anabolic drug teriparatide, recombinant agent used for the therapy of severe skeletal defects in osteoporosis, in dental surgery. Biologic agents belimumab, abatacept, and epratuzumab are clinically tested in active forms of primary Sjőgren's syndrome. Live atenuated vaccine targeted against varicella-zoster virus in older individuals serves in the prophylaxis of the herpes zoster.

Conclusion: Potential benefit of the above mentioned substances and devices might be seen in dental medicine disciplines.

Keywords: aciclovir; cortisol; labial herpes; herpes simplex virus; varicella-zoster virus; herpes zoster; recurrent aphthous ulcers; gingivectomy; periodontology; hyposialia; xerostomia; Sjőgren's syndrome; substitution; stimulation; teriparatide; osteonecrosis; jaw bone; biologic therapy; belimumab; abatacept; epratuzumab; clinical study; active substance; medical device; local therapy; systemic therapy

Published: September 1, 2015  Show citation

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Slezák R, Janovská Z, Lindrová I, Radochová V. New Pharmacotherapeutic Posssibilities in Contemporary Dentistry. Čes. stomatol. Prakt. zub. lék. 2015;115(3):27-33. doi: 10.51479/cspzl.2015.021.
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    References

    1. Bashutski, J. D., Eber, R. M., Kinney, J. S., Benavides, E., Maitra, S., Braun, T. M., Giannobile, W. V., McCauley, L. K.: Teriparatide and osseous regeneration in the oral cavity. N. Engl. J. Med., roč. 363, 2010, č. 25, s. 2396-2405. Go to original source... Go to PubMed...
    2. DGM Italia. http://www.dmgit.com
    3. Evans, T. G., Bernstein, D. I, Raborn, G. W., Harmenberg, J., Kowalski, J., Spruance, S. L.: Double-blind, randomized, placebo-controlled study of topical 5% aciclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis. Antimicrob. Agents Chemother., roč. 46, 2002, č. 6, s. 1870-1874. Go to original source... Go to PubMed...
    4. Hull, C. M., Brunton, S.: The role of topical 5% acyclovir and 1% hydrocortisone cream (Xerese&trade) in the treatment of recurrent herpes simplex labialis. Postgrad. Med., roč. 122, 2010, č. 5, s. 1-6. Go to original source... Go to PubMed...
    5. Kost, R. G., Straus, S. E.: Postherpetic neuralgia-pathogenesis, treatment, and prevention. N. Engl. J. Med., roč. 335, 1996, č. 1, s. 32-42. Go to original source... Go to PubMed...
    6. Levin, M. J., Smith, J. G., Kaufhold, R. M., Barber, D., Hayward, A. R., Chan, C. Y., et al.: Decline in varicella-zoster virus (VZV) - specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine. J. Infect. Dis., roč. 188, 2003, č. 9, s. 1336-1344. Go to original source... Go to PubMed...
    7. Mariette, X., Seror, R., Quartuccio, L., Baron, G., Salvin, S., Fabris, M., Desmoulins, F., Nocturne, G., Ravaud, P., De Vita, S.: Efficacy and safety of belimumab in primary Sjögren's syndrome: results of the BELISS open-label phase II study. Ann. Rheum. Dis., roč. 74, 2015, č. 3, s. 526-531. Go to original source... Go to PubMed...
    8. Meijer, J. M., Pijpe, J., Bootsma, H., Vissink, A., Kallenberg, C. G. M.: The future of biologic agents in the treatment of Sjögren's syndrome. Clin. Rev. Allergy Immunol., roč. 32, 2007, č. 3, s. 292-297. Go to original source... Go to PubMed...
    9. Meiners, P. M., Vissink, A., Kroese, F. G., Spijkervet, F. K., Smitt-Kamminga, N. S., Abdulahad, W. H., Bulthuis-Kuiper, J., Brouwer, E., Arends, S., Bootsma, H.: Abatacept treatment reduces disease activity in early primary Sjögren's syndrome (open-label proof of concept ASAP study). Ann. Rheum. Dis., roč. 73, 2014, č. 7: s. 1393-1396. Go to original source... Go to PubMed...
    10. Miller, C. S.: Teriparatide's potential role in jaw bone related diseases. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 112, 2011, č. 6, s. 703-705. Go to original source... Go to PubMed...
    11. Narongroeknawin, P., Danila, M. I., Humphreys, L. G., Jr., Barasch, A., Curtis, J. R.: Bisphosphonate-associated osteonecrosis of the jaw, with healing after teriparatide: a review of the literature and a case report. Spec. Care Dent., roč. 30, 2010, č. 2, s. 77-82. Go to original source... Go to PubMed...
    12. Ohbayashi, Y., Miyake, M., Sawai, F., Minami, Y., Iwasaki, A., Matsui, Y.: Adjunct teriparatide therapy with monitoring of bone turnover markers and bone scintigraphy for bisphosphonate-related osteonecrosis of the jaw. Oral Surg. Oral Med. Oral Pathol. Oral Radiol., roč. 115, 2013, č. 4, s. 31-37. Go to original source... Go to PubMed...
    13. Oxman, M. N., Levin, M. J., Johnson, G. R., Schmader, K. E., Straus, S. E., Gelb, L. D., et al.: A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N. Engl. J. Med., roč. 352, 2005, č. 22, s. 2271-2284. Go to original source... Go to PubMed...
    14. Oxman, M. N., Levin, M. J. Shingles Prevention Study Group.: Vaccination against herpes zoster and postherpetic neuralgia. J. Infect. Dis., roč. 197, 2008, Suppl. 2, s. S228-S236. Go to original source... Go to PubMed...
    15. Rosa, J.: Teriparatid. Remedia, roč. 18, 2008, č. 5, s. 338-344.
    16. Ship, J. A., McCutcheon, J. A., Spivakovsky, S., Kerr, A. R.: Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. J. Oral. Rehab., roč. 34, 2007, č. 10, s. 724-732. Go to original source... Go to PubMed...
    17. Slezák, R., Berglová, I., Krejsek, J.: Xerostomie, hyposialie, sicca syndrom-kvantitativní poruchy salivace. Vnitř. Lék., roč. 57, 2011, č. 4, s. 339-346.
    18. Slezák, R., Lindrová, I., Buchta, V., Paulusová, V., Šustová, Z., Kopecký, O., Ryšková, L.: Přehled novějších možností ve farmakoterapii nemocí ústní sliznice, slinných žláz a parodontu. Čes. Stomat., roč. 113, 2013, č. 3, s. 64-73. Go to original source...
    19. Slezák, R., Ryšková, L., Paulusová, V., Šustová, Z., Berglová, I., Buchta, V.: Nové možnosti ve farmakoterapii chorob parodontu a ústní sliznice. Čes. Stomat., roč. 112, 2012, č. 2, s. 15-22. Go to original source...
    20. Slezák, R., Šustová, Z., Nováková, V.: Pokroky ve farmakoterapii chorob ústní sliznice. Čes. Stomat., roč. 109, 2009, č. 1, s. 7-14.
    21. Steinfeld, S. D., Tant, L., Burmeister, G. R., Teoh, N. K. W., Wegener, W. A., Goldenberg, D. M., Pradier, O.: Epratuzumab (humanized anti-CD22 antibody) in primary Sjogren's syndrome: An open-label Phase I/II study. Arthritis Res. Therap., roč. 8, 2006, č. 4, s. R129. doi:10.1186/ar2018. Go to original source... Go to PubMed...
    22. Subramanian, G., Cohen, H. V., Quek, S. Y.: A model for the pathogenesis of bisphosphonate-associated osteonecrosis of the jaw and teriparatide's potential role in its resolution. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 112, 2011, č. 6, s. 744-753. Go to original source... Go to PubMed...
    23. URGO. http://www.filmogel.com
    24. Weller, T. H.: Varicella and herpes zoster. Changing concepts of the natural history, control, and importance of a not-so-benign virus. N. Engl. J. Med., roč. 335, 1983, č. 23, s. 1434-1440. Go to original source... Go to PubMed...

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