Čes. stomatol. Prakt. zub. lék. (Czech Dental Journal) 2004; 104(2): 57-70
The Relationship between Salivary Thiobarbituric Acid Reacting Substancesand Parodont Status and Its Origin in Parodonthopathies
- 1 Lekárska fakulta, Univerzita Komenského, Bratislava
- 2 Prírodovedecká fakulta, Univerzita Komenského, Bratislava
- 3 Medizinische Fakultät, Georg-August Universität, Göttingen
- 4 I. stomatologická klinika, Univerzita Komenského, Bratislava
- 5 III. stomatologická k
Introduction: Thiobarbituric acid reacting substances (TBARS) are products of lipoperoxidation. Lipoperoxidation damages various tissues by reactive oxygen intermediates(ROI) and thus TBARS are generally considered as markers of oxidation stress and lipidimpairment.
Aim: The aim of this project was to find possible nexus between chosen characteristics of immune system, parodont status and TBARS concentrations in saliva in healthy volunteers. In addition, we tried to find the origin of TBARS in saliva in patients with parodontopathies, where we focused on entire or partially plasmatic TBARS passage to saliva hypothesis. Subjects & Methods. Our volunteers consisted of 31 young healthy men and 29 young healthy women with an average age of 21.5 ± 1.4 yr (Study A) and 15 patients in age interval of 20-60 yr (Study B). Parodont status was examined using PBI (Papillary-Bleeding-Index). TBARS were determined, in plasma and saliva, spectrofluorometrically (λex = 515 nm, λem =553 nm). Testosterone (TST) levels were measured using radioimmunoassay. Immunoglobulines and other haematological parametres were determined turbidimetrically.
Results: Study A. The women with higher PBI levels had shown higher concentrations of TST (p
Keywords: TBARS; malondialdehyde; salivary testosterone; PBI; parodontopathies; oxidation stress
Published: June 1, 2004 Show citation
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