Čes. stomatol. Prakt. zub. lék. (Czech Dental Journal) 2012; 112(1): 15-22 | DOI: 10.51479/cspzl.2012.003

Advances in the Pharmacotherapy of Periodontal and Oral Mucosal Diseases

R. Slezák1,*, L. Ryšková2, V. Paulusová1, Z. Šustová1, I. Berglová1, V. Buchta2
1 Stomatologická klinika LF UK a FN, Hradec Králové
2 Ústav klinické mikrobiologie LF UK a FN, Hradec Králové

Introduction: There are many of drugs useful for topical or systemic treatment of diseases of periodontal tissue and oral mucous membrane. Their correct administration and efficacy depend strictly on adeqnate of information regarding their properties.

Aim: The review deals with some drugs newly available in Czech Republic and related therapeutic procedures used in the treatment of periodontal and mucosal diseases.


Therapeutic agents: For topical chemical inhibition of the dental plaque are dedicated octenidine, kationic antiseptic pyridine derivate, and combination of classic bis-biguanide derivate chlorhexidine with aromatic agent eugenol. As adjuvant chemotherapeutics in the treatment of periodontitis serve systems for targeted antimicrobial photodynamic therapy based on the use of photosensitizers as producers of the singlet oxygen, namely toluidine blue O and methylen blue. The source of monochromatic light for their pohotoactivation is laser device. Saturated alcohol docosanol with antiviral acitivity serves in topical therapy of labial herpes. Vanillinamide alkaloid capsaicine is selective agonist of vanilloid receptore TRPV 1 of sensitive nerves. Patch product Qutenza has been recently used for higly effective topical treatment of neuropatic pain. It could be potentially very useful agent in the treatment of some forms of atypical facial pain. Irradiation of salivary glands results in association with its dosis in the damage of various grade of the glandular parenchyma associated with postirradiative hyposialia. Cytoprotective prodrug amifostine releases active thiol after its dephosphorylation. It is recommended for the protection of the glandular parenchyma against adverse effects of antitumorous drugs and therapeutic irradiation in the region of the head and neck.

Conclusion: Spectrum of therapeutic agents useful in the treatment of periodontal and mucosal diseases raises permanently. Efficacy of their application is connected with sufficient information of professionals and correct and early diagnosis of the disease, as well.

Keywords: periodontal tissue; oral mucous membrane; antimicrobial photodynamic therapy; toluidine blue O; methylen blue; octenidine; chlorhexidine; eugenol; docosanol; capsaicine; amifostine

Published: March 1, 2012  Show citation

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Slezák R, Ryšková L, Paulusová V, Šustová Z, Berglová I, Buchta V. Advances in the Pharmacotherapy of Periodontal and Oral Mucosal Diseases. Čes. stomatol. Prakt. zub. lék. 2012;112(1):15-22. doi: 10.51479/cspzl.2012.003.
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    References

    1. Al-Zahrani, M. S., Bamshmous, S. O., Alhassani, A. A., Al-Sherbini, M. M.: Short-term effect of photodynamic therapy on periodontal status and glycemic kontrol of patiens with diabetes. J. Periodontol., roč. 80, 2009, č. 10, s. 1568-1573. Go to original source... Go to PubMed...
    2. AISLP Kompendium:0016968 Ethyol inj. plv. sol.
    3. Beiswanger, B. B., Mallatt, M. E., Mau, M. S., Jackson, R. D., Hennon, D. K.: The clinical effects of a mouthrinse containing 0.1% octenidine. J. Dent. Res., roč. 69, 1990, č. 2, s. 454-457. Go to original source... Go to PubMed...
    4. Bhalla, M., Thami, G. P.: Acute urticaria due to dental eugenol. Allergy, roč. 58, 2003, č. 2, s. 158. Go to original source... Go to PubMed...
    5. Bohuslavizki, K. H., Brenner, W., Klutmann, S., Hübner, R.-H., Lassmann, S., Feyerabend, B., Luttges, J., Tinnemeyer, S., Clausen, M., Henze, E.: Radioprotection of salivary glands by amifostine in high-dose radioiodine therapy. J. Nucl. Med., roč. 39, 1998, s. 1237-1242. Go to PubMed...
    6. Braham, P., Herron, C., Street, C., Darveau, R.: Antimicrobial photofynamic therapy may promote periodontal healing through multiple mechanisms. J. Periodontol., roč. 80, 2009, č. 11, s. 1790-1798. Go to original source... Go to PubMed...
    7. Cervitec Liquid Antibacterial mouth rinsing solution. Ivoclar Vivadent Technical Data Sheet. Dostupné z: www.ivoclarvivadent.com.
    8. Erazaban™ 10% Krém Docosanolum. Příbalový leták.
    9. Flek, V.: Qutenza v klinických studiích. Bolest, roč. 13, 2010, č. 4, s. 197-199.
    10. Fricová, J.: Postherpetická neuralgie - kasuistika. Bolest, roč. 12, 2007, č. 3, s. 144-145.
    11. Ghannoum, M. A., Abu Elteen, K., Stretton, R. J., Whittaker, P. A.: Effects of octenidine and pirtenidine on adhesion of Candida species to human buccal epithelial cells in vitro. Arch. Oral Biol., roč. 35, 1990, č. 4, s. 249-253. Go to original source... Go to PubMed...
    12. Guénette, S. A., Ross, A., Marieer, J. F., Beaudry, F., Vachon, P.: Pharmacokinetics of eugenol and its effects on thermal hypersensitivity in rats. Eur. J. Pharmacol., roč. 562, 2007, č. 1-2, s. 60-67. Go to original source... Go to PubMed...
    13. Katz, D. H., Marcelletti, J F., Khalil, M. H., Pope, L. E., Katz, L. R.: Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex. Proc. Natl. Acad. Sci. U. S. A., roč. 88, 1991, č. 2, s. 10825-10829. Go to original source... Go to PubMed...
    14. Koukourakis, M. I.: Amifostine in clinical oncology: current use and future applications. Anti-cancer Drugs, roč. 13, 2002, č. 3, s. 181-209. Go to original source... Go to PubMed...
    15. Kotas, R.: Primární nebo sekundární bolest hlavy? Bolest, roč. 12, 2009, č. 2, s. 73-77.
    16. Leung, D. T., Sacks, S. L.: Docosanol: a topical antiviral for herpes labialis. Exper. Opin. Pharmacother., roč. 5, 2004, č. 12, s. 2567-2571. Go to original source...
    17. Ma, C., Xie, J., Chen, Q., Wang, G., Zuo, S.: Amifostine for salivary glands in high-dose radioactive iodine treated differentiated thyroid cancer. Cochrane Database of Systematic Reviews 2009, č. 4. Art. No.: CD007956. DOI: 10.1002/ /14651858.CD007956.pub2 Go to original source...
    18. Metodické pokyny pro farmakoterapii bolesti. Přepracované vydání. Bolest, roč. 12, 2009, Suppl 2.
    19. Paleček, J.: Úloha TRPV1 v modulaci bolesti v experimentálních a klinických studiích. Bolest, roč. 13, 2010, Suppl. 1, s. 32-33.
    20. Pope, L. E., Marcelletti, J. F., Katz, L. R., Lin, J. Y., Katz, D. H., Parish, M. L., Sper, P. G.: The anti-herpes simplex virus activity of n-docosanol includes inhibition of the viral entry process. Antiviral Res., roč. 40, 1998, č. 1-2, s. 85-94. Go to original source... Go to PubMed...
    21. Porter, S. R., Scully, C., Hegarty, A. M.: An update of the etiology and management of xerostomia. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 97, 2004, č. 1, s. 28-46. Go to original source... Go to PubMed...
    22. Rohrer, N., Widmer, A. F., Waltimo, T., Kulik, E. M., Weiger, R., Filipuzzi-Jenny, E., Walter, C.: Antimicrobial efficacy of 3 oral antiseptics containing octenidine, polyhexamethylene biguanide, or Citroxx: can chlorhexidine be replaced? Infect. Control Hosp. Epidemiol., vol. 31, 2010, č. 7, s. 733-739. Go to original source... Go to PubMed...
    23. Ryskova, L., Buchta, V., Slezak, R.: Photodynamic antimicrobial therapy. Centr. Eur. J. Biol., roč. 5, 2010, č. 4, s. 400-406. Go to original source...
    24. Sarrami, N., Pemberton, M. N., Thornhill, M. H., Theaker, E. D.: Adverse reactions associated with the use of eugenol in dentistry. Br. Dent. J., roč. 193, 2002, č. 2, s. 253-255. Go to original source... Go to PubMed...
    25. Sedlock, D. M., Bailey, D. M.: Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent. Antimicrob. Agents Chemother., roč. 28, 1985, č. 6, s. 786-790. Go to original source... Go to PubMed...
    26. Sennhenn-Kirchner, S., Wolff, N., Klaue, S., Mergeryan, H., Borg-von Zepelin, M.: Decontamination efficacy of antiseptic agents on in vivo grown biofilms on rough titanium surfaces. Quintessence Int., roč. 40, 2009, č. 10, s. e80-e88.
    27. Schupp, C. J., Holland-Cunz, S.: Persistent subcutaneous oedema and aseptic fatty tissue necrosis after using octenisept. Eur. J. Pediatr. Surg., roč. 19, 2009, č. 3, s. 179-183. Go to original source... Go to PubMed...
    28. Slezák, R.: Preklinická parodontologie. 1. vyd. Hradec Králové, NUCLEUS HK, 2007, s. 69-76.
    29. Slezák, R., Bittner, J., Ettlerová, K.: Malé ilustrované repetitorium. Alergická reakce s projevy v dutině ústní. LKS, roč. 14, 2004, č. 3, s. 19-20.
    30. Slezák, R., Šustová, Z., Nováková, V.: Pokroky ve farmakoterapii chorob ústní sliznice. Čes. Stomat., roč. 109, 2009, č. 1, s. 7-14.
    31. Takasaki, A. A., Aoki, A., Mizutani, K., Schwarz, F., Sculean, A., Wang, C.-Y., Koshi, G., Romanos, G., Ishikawa, I., Ozimi, Y.: Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases. Periodontology 2000, roč. 51, 2009: s. 109-140. Go to original source... Go to PubMed...
    32. Tandjung, L., Waltimo, T., Hauser, I., Heide, P., Decker, E. M., Weiger, R.: Octenidine in root canal and dentine disinfection ex vivo. Int. Endod. J., roč. 40, 2007, č. 11, s. 845-851. Go to original source... Go to PubMed...
    33. Tirali, R. E., Turan, Y., Akal, N., Karahan, Z. C.: In vitro antimicrobial activity of several concentrations of NaOCl and Octenisept in elimination of endodontic pathogens. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 108, 2009, č. 5, s. e117-e120. Go to original source... Go to PubMed...
    34. van Winkelhoff, A. J., Winkel, E. G.: Antibiotics in periodontics: Right or wrong? J. Periodontol., roč. 80, 2009, č. 10: s. 1555-1558. Go to original source... Go to PubMed...
    35. Vondráčková, D.: Farmakoterapie neuropatické bolesti. Klin. Farmakol. Farm., roč. 23, 2009, č. 4, s. 181-186.
    36. Wainwright, M.: Antimicrobial application - photodynamic antimicrobial chemotherapy. In: Wainwright, M.: Photosensitizers in biomedicine. 1. vyd., Wiley-Blackwell, A John Wiley & Sons, Ltd., 2009, s. 237-258.

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