Čes. stomatol. Prakt. zub. lék. (Czech Dental Journal) 2014; 114(1): 3-6 | DOI: 10.51479/cspzl.2014.001

Central Giant Cell Granuloma - Conservative Treatment with Intralesional Application of Corticosteroids

J. Zelinka*, J. Blahák, O. Bulik
Klinika ústní, čelistní a obličejové chirurgie LF MU a FN, Brno

Objective: Central giant cell granuloma (CGCG) is a benign lesion of the jaws although sometimes it can be locally aggressive. CGCG commonly occurs in children and young adults. The traditional treatment of CGCG involves surgery ranging from single enucleation to en bloc resection, which often leads to mutilation of patients. An alternative method is intralesional injection of corticosteroid, which we successfully used in treatment of 15 years old patient with large lesion so the patient didn't have to undergo partial resection of mandible.

Keywords: giant cell granuloma; corticosteroids; triamcinolone; intralesional injections

Published: March 1, 2014  Show citation

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Zelinka J, Blahák J, Bulik O. Central Giant Cell Granuloma - Conservative Treatment with Intralesional Application of Corticosteroids. Čes. stomatol. Prakt. zub. lék. 2014;114(1):3-6. doi: 10.51479/cspzl.2014.001.
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References

  1. Abdo, E. N., Alves, L. C. F., Rodriques, A. S., Mesquita, R. A., Gomez, R. S.: Treatment of a central giant cell granuloma with intralesional corticosteroid. Br. J. Oral Maxillofac. Surg., roč. 43, 2005, č. 1, s. 74-76. doi 10.1016/j.bjoms.2004.08.015. PMID: 15620781. Go to original source... Go to PubMed...
  2. Da Silva, N. G. J., Carreira, A. S. D., Pedreira, E. N., Tuji, F. M., Ortega, K. L., de Jesus Viana Pinheiro, J.: Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections. Head Face Med., roč. 8, 2012, s. 23. doi 10.1186/1746-160X-8-23. PMID: 22913518. Go to original source... Go to PubMed...
  3. de Lange, J., van den Akker, H. P., Klip, H.: Incidence and disease-free survival after surgical therapy of central giant cell granulomas of the jaw in The Netherlands: 1990-1995. Head & neck, roč. 26, 2004, č. 9, s. 792-795. doi 10.1002/hed.20069. PMID: 15350025. Go to original source... Go to PubMed...
  4. de Lange, J., van Rijn, R. R., van den Berg, H., van den Akker, H. P.: Regression of central giant cell granuloma by a combination of imatinib and interferon: a case report. Br. J. Oral Maxillofac. Surg., roč. 47, 2009, č. 1, s. 59-61. doi 10.1016/j.bjoms.2008.05.013. PMID: 18656288. Go to original source... Go to PubMed...
  5. Flanagan, A. M., Nui, B., Tinkler, S. M., Horton, M. A., Williams, D. M., Chambers, T. J.: The multinucleate cells in giant cell granulomas of the jaw are osteoclasts. Cancer, roč. 62, 1988, č. 6, s. 1139-1145. PMID: 2457425. Go to original source...
  6. Chuong, R., Kaban, L. B., Kozakewich, H., Perez-Atyde, A.: Central giant cell lesions of the jaws: a clinicopathologic study. J. Oral Maxillofac. Surg., roč. 44, 1986, č. 9, s. 708-713. PMID: 3462363. Go to original source... Go to PubMed...
  7. Jacoway, J. R., Howell, F. V., Terry, B. C.: Central giant cell granuloma - an alternative to surgical therapy. Oral Surg., 1988, č. 5, s. 572.
  8. Jaffe, H. L.: Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-oseous) dysplasia of the jawbones. Oral Surg. Oral Med. Oral Pathol., roč. 6, 1953, č. 1, s. 159-175. PMID: 13026160. Go to original source... Go to PubMed...
  9. Kaffe, I., Ardekian, L., Taicher, S., Littner, M. M., Buchner, A.: Radiologic features of central giant cell granuloma of the jaws. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 81, 1996, č. 6, s. 720-726. PMID: 8784905. Go to original source... Go to PubMed...
  10. Kramer, I. R., Pindborg, J. J., Shear, M.: The World Health Organization histological typing of odontogenic tumours. Introducing the second edition. Eur. J. Cancer, B. Oral Oncol., roč. 29B, 1993, č. 3, s. 169-171. PMID: 8298419. Go to original source... Go to PubMed...
  11. Kruse-Lösler, B., Diallo, R., Gaertner, C., Mischke, K. L., Joos, U., Kleinheinz, J.: Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 101, 2006, č. 3, s. 346-354. doi 10.1016/j.tripleo.2005.02.060. PMID: 16504869. Go to original source... Go to PubMed...
  12. Nogueira, R. L. M., Teixeira, R. C., Cavalcante, R. B., Ribeiro, R. A., Rabenhosrt, R. A. B.: Intralesional injection of triamcinolone hexacetonide as an alternative treatment for central giant-cell granuloma in 21 cases. Int. J. Oral Maxillofac. Surg., roč. 39, 2010, č. 12, s. 1204-1210. doi 10.1016/j.ijom.2010.06.015. PMID: 20674272. Go to original source... Go to PubMed...
  13. O'Connell, J. E., Kearns, G. J.: Aggressive giant cell granuloma of the jaws treated with interferon alpha: a report of two cases. Ir. J. Med. Sci., roč. 182, 2013, č. 2, s. 163-170. doi 10.1007/s11845-012-0858-x. PMID: 23099991. Go to original source... Go to PubMed...
  14. Sezer, B., Koyuncu, B., Gomel, M., Günbay, T.: Intralesional corticosteroid injection for central giant cell granuloma: A case report and review of the literature. Turk. J. Pediatr., roč. 47, 2005, s. 75-81.
  15. Terry, B. C., Jacoway, J. R.: Management of central giant cell lesion: an alternative to surgical therapy. Oral Maxillofac. Surg. Clin. North Am., 6, 1994, s. 579-600. Go to original source...
  16. Van Damme, P. A., Mooren, R. E.: Differentiation of multiple giant cell lesions, Noonan-like syndrome, and (occult) hyperparathyroidism. Case report and review of the literature. Int. J. Oral Maxillofac. Surg., roč. 23, 1994, č. 1, s. 32-36. PMID: 8163857. Go to original source... Go to PubMed...
  17. Vered, M., Shohat, I., Buchner, A., Dayan, A., Taicher, S.: Calcitonin nasal spray for treatment of central giant cell granuloma: clinical, radiological, and histological findings and immunohistochemical expression of calcitonin and glucocorticoid receptors. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 104, 2007, č. 2, s. 226-239. doi 10.1016/j.tripleo.2006.05.020. PMID: 1763009. Go to original source... Go to PubMed...
  18. Whitaker, S. B., Waldron, C. A.: Central giant cell lesions of the jaws. A clinical, radiologic, and histopathologic study. Oral Surg. Oral Med. Oral Pathol., roč. 75, 1993, č. 2, s. 199-208. PMID: 8426719. Go to original source... Go to PubMed...

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