Čes. stomatol. Prakt. zub. lék. (Czech Dental Journal) 2014; 114(3): 53-59 | DOI: 10.51479/cspzl.2014.010

The Assessment of the Biocompatibility of Dental Alloys and Alloys for Dental Amalgam. Part First

Z. Broukal1,*, V. Fialová1, J. Novotný2
1 Ústav klinické a experimentální stomatologie 1. LF UK a VFN, Praha
2 SAFINA a.s., Praha

Background: Dental alloys are widely used in applications where they come for a long time into contact with oral epithelium, connective tissue or alveolar bone. Hence their biocompatibility is one of the critical requirements for use in clinical dentistry. This review of literature is intended as an overview of the risk exposure of the human body to metals from dental alloys and the possibility of examining the model conditions in vitro and in vivo before placing them on the market and put into use. Dental alloys are metallurgically complex ones and with regard to their composition. They are divided into gold, silver and palladium based alloys and non-precious alloys (cobalt, chromium, nickel). Crucial features of alloys in terms of their biocompatibility are their corrosion properties. The individual components of alloys released into the oral environment and the organism due to the in situ corrosion processes can cause local and systemic toxicity, and therefore it is necessary the alloys in the preclinical stage to properly investigate. Attention is focused especially on local toxicity, since systemic toxicity from dental alloys has not been demonstrated. Standard contact cytotoxicity tests whether performed in vitro in cell cultures or in vivo in laboratory animals simulate the situation in the clinical use only partially, and therefore it is necessary to take into consideration the general toxicological properties of the individual metals in dental alloys.

Conclusion: In the first part of the literature review of the dental alloys biocompatibility and its testing the data gained from the last fifteen to twenty years are summarized.

Keywords: dental alloys; biocompatibility; system and contact toxicity; corrosion of dental alloys

Published: September 1, 2014  Show citation

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Broukal Z, Fialová V, Novotný J. The Assessment of the Biocompatibility of Dental Alloys and Alloys for Dental Amalgam. Part First. Čes. stomatol. Prakt. zub. lék. 2014;114(3):53-59. doi: 10.51479/cspzl.2014.010.
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    References

    1. Bader, J., Rozier, R. G., McFall, W. T.: The effect of crown receipt on measures of gingival status. J. Dent. Res., roč. 70, 1991, č. 10, s. 1386-1389. Go to original source... Go to PubMed...
    2. Black, J.: Systemic effects of biomaterials. Biomaterials, roč. 5, 1984, č. 1, s. 11-18. Go to original source...
    3. Brune, D.: Metal release from dental biomaterials. Biomaterials, roč. 7, 1986, č. 3, s. 163-175. Go to original source...
    4. Bumgardner, J. D., Lucas, L. C.: Corrosion and cell culture evaluations of nickel-chromium dental casting alloys. J. Appl. Biomater., roč. 5, 1994, č. 3, s. 203-213. Go to original source... Go to PubMed...
    5. Craig, R. G., ed.: Restorative dental materials. 10th ed. St Louis, Mosby - Yearbook 1997, p. 146-153, 387-389.
    6. Flint, G. N., Packirisamy, S.: Systemic nickel: the contribution made by stainless-steel cooking utensils. Contact Dermatitis, roč. 32, 1995, č. 4, s. 218-224. Go to original source... Go to PubMed...
    7. Fontana, M. G.: Corrosion engineering. 3rd ed. New York, McGraw Hill, 1986. p. 165-200.
    8. Geis-Gerstorfer, J., Sauer, K. H., Pässler, K.: Ion release from Ni-Cr-Mo and Co-Cr-Mo casting alloys. Int. J. Prosthodont., roč. 4, 1991, č. 2, s. 152-158.
    9. Goyer, R. A.: Toxic effects of metals. In Klaassen, C. D., Amdur, M. O., Doull, J., eds. Cassarett and Doull's toxicology. 3rd ed. New York, Macmillan, 1986. p. 582-635.
    10. Hao, S. Q., Lemons, J. E.: Histology of dog dental tissues with Cu-based crowns. J. Dent. Res., roč. 68, 1989, Spec. issue, s. 322 (abstract 1125).
    11. Hodgson, E., Levi, P. E., eds.: Modern toxicology. New York, Elsevier, 1987. p. 123-131.
    12. Hogan, D., Ledet, J. J.: Impact of regulation on contact dermatitis. Dermatol. Clin., roč. 27, 2009, č. 3, s. 385-394. Go to original source... Go to PubMed...
    13. Jacobs, J. J., Skipor, A. K., Black, J., Manion, L. M., Schavocky, J., Paprosky, W. P., et al.: Serum titanium transport in patients following primary total hip replacement: a 2 year prospective study. Trans. Soc. Biomater., roč. 16, 1993, č. 1, s. 16, 21-27.
    14. Jacobs, J. J., Skipor, A. K., Urban, R. M., Manion, L. M., Gilbert, J. L., Black, J.: Serum and urine metal content in patients with fretting corrosion of modular femoral THR components. Trans. Soc. Biomater., roč. 17, 1994, č. 10, s. 320.
    15. Lamster, I. B., Kalfus, D. I., Steigerwald, P. J., Chasens, A. I.: Rapid loss of alveolar bone associated with nonprecious alloy crowns in two patients with nickel hypersensitivity. J. Periodontol., roč. 58, 1987, č. 7, s. 486-492. Go to original source... Go to PubMed...
    16. Lee, J. M., Salvati, E. A., Betts, F., DiCarlo, E. F., Doty, S. B., Bullough, P. G.: Size of metallic and polyethylene debris particles in failed cemented total hip replacements. J. Bone Joint Surg. Br., roč. 74, 1992, č. 3, s. 380-384. Go to original source... Go to PubMed...
    17. Lugowski, S. J., Smith, D. C., McHugh, A. D., Van Loon, J. C.: Release of metal ions from dental implant materials in vivo: determination of Al, Co, Cr, Mo, Ni, V, and Ti in organ tissue. J. Biomed. Mater. Res., roč. 25, 1991, č. 12, s. 1443-1458. Go to original source... Go to PubMed...
    18. Mallineni, S. K., Nuvvula, S., Matinlinna, J. P., Yiu, C. K., King, N. M.: Biocompatibility of various dental materials in contemporary dentistry: a narrative insight. J. Investig. Clin. Dent., roč. 4, 2013, č. 1, s. 9-19. Go to original source... Go to PubMed...
    19. Moore, W. Jr., Hysell, D., Crocker, W., Stara, J.: Biological fate of 103Pd in rats following different routes of exposure. Environ. Res., roč. 8, 1974, č. 2, s. 234-240. Go to original source... Go to PubMed...
    20. Phielepeit, T., Legrum, W., Netter, K. J., Kiötzer, W. T.: Different effects of intraperitoneally and orally administered palladium chloride on the hepatic monooxygenase system of male mice. Arch. Toxicol. Suppl., roč. 13, 1989, s. 357-362. Go to original source... Go to PubMed...
    21. Rechmann, P.: Lamms and ICP-MS detection of dental metallic compounds in not-discolored human gingiva. J. Dent. Res., roč. 71, 1992, Spec. issue, s. 599 (abstract 672).
    22. Reclaru, L., Meyer, J. M.: Study of corrosion between a titanium implant and dental alloys. J. Dent., roč. 22, 1994, č. 3, s. 159-168. Go to original source... Go to PubMed...
    23. Schmalz, G., Arenholt-Bindslev, D., Hiller, K. A., Schweikl, H.: Epithelium fibroblast co-culture for assessing mucosal irritancy of metals used in dentistry. Eur. J. Oral Sci., roč. 105, 1997, č. 1, s. 85-91. Go to original source... Go to PubMed...
    24. Schmalz, G.: The biocompatibility of non-amalgam filling materials. Eur. J. Oral Sci., roč. 106, 1998, č. 2, Pt 2, s. 696-706. Go to original source... Go to PubMed...
    25. Setz, J., Diehl, J.: Gingival reaction on crowns with cast and sintered metal margins: a progressive report. J. Prosthet. Dent., roč. 71, 1994, č. 5, s. 442-446. Go to original source... Go to PubMed...
    26. Shigeto, N., Yanagihara, T., Murakami, S., Hamada, T.: Corrosion properties of soldered joints. Part II: corrosion pattern of dental solder and dental nickel-chromium alloy. J. Prosthet. Dent., roč. 66, 1991, č. 5, s. 607-610. Go to original source... Go to PubMed...
    27. Stenberg, T.: Release of cobalt from cobalt chromium alloy constructions in the oral cavity of man. Scand. J. Dent. Res., roč. 90, 1982, č. 6, s. 472-479. Go to original source... Go to PubMed...
    28. Wataha, J. C., Craig, R. G., Hanks, C. T.: The release of elements of dental casting alloys into cell-culture medium. J. Dent. Res., roč. 70, 1991, č. 6, s. 1014-1018. Go to original source... Go to PubMed...
    29. Wataha, J. C., Hanks, C. T., Craig, R. G.: In vitro synergistic, antagonistic, and duration of exposure effects of metal cations on eukaryotic cells. J. Biomed. Mater. Res., roč. 26, 1992, č. 10, s. 1297-1309. Go to original source... Go to PubMed...
    30. Wataha, J. C., Malcolm, C. T., Hanks, C. T.: Correlation between cytotoxicity and the elements released by dental casting alloys. Int. J. Prosthodont., roč. 8, 1995, č. 1, s. 9-14.
    31. Wataha, J. C., Craig, R. G., Hanks, C. T.: Element release and cytotoxicity of Pd-Cu binary alloys. Int. J. Prosthodont., roč. 8, 1995, č. 3, s. 228-232.
    32. Wataha, J. C, Lockwood, P. E.: Release of elements from dental casting alloys into cell-culture medium over 10 months. Dent. Mater., roč. 14, 1998, č. 2, s. 158-163. Go to original source... Go to PubMed...
    33. Wataha, J. C., Lockwood, P. E., Vuillème, M. N., Zürcher, M. H.: Cytotoxicity of Au-based dental solders alone and on a substrate alloy. J. Biomed. Mater. Res., roč. 48, 1999, č. 6, s. 786-790. Go to original source...
    34. Wataha, J. C.: Biocompatibility of dental casting alloys: A review. J. Prosthet. Dent., roč. 83, 2000, č. 2, s. 223-224. Go to original source... Go to PubMed...
    35. Wiester, M. J.: Cardiovascular actions of palladium compounds in the unanesthetized rat. Environ. Health Perspect, roč. 12, 1975, č. 1, s. 41-44. Go to original source... Go to PubMed...

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